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Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

Brain Sketch


Semax is a nootropic that is known for its neuroprotective and neurorestorative effects.   The neuroactive peptide possesses neurotrophic, neuroregulatory, and neuroprotective properties in the central nervous system.   Semax belongs to the melanocortin family of compounds which includes adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone.   Semax is currently used clinically in Russia and Ukraine for treatment of cranial and head injuries like stroke and TBI, as well as for neurodegenerative diseases like Alzheimer's and Parkinson's Disease. In addition to its nootropic effects, Semax has also been shown to have anti-inflammatory, antioxidant, regenerative, vasodilatory, and neuroprotective properties.

Semax has been shown to rapidly elevate the levels and expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) 

Semax Nootropic Cognitive Benefits

  • Enhanced Overall Cognition

  • Increased BDNF production

  • Increased NGF production

  • Improved Focus and Concentration

  • Increased Memory Capacity

  • Increased Memory Recall

  • Improved Problem Solving Abilities

  • Neuroprotective: Prevent Cognitive Decline 

  • Promotes Neurogenesis

  • Increases Neuroplasticity

  • Anti-Anxiety 

  • Increased Stress Resilience

  • Improved Mood Stability

  • Improved Sleep

Other benefits of Semax
  • Anti-inflammatory

  • Antioxidant

  • Regenerative effects

  • Vasodilatory effect

  • Accelerated GI Healing

  • Elimination of Bacteria and Pathogens

Semax side effects

Research shows that Semax is very well-tolerated by most users, with few reported side effects. However, some users experience a slight burning sensation in the nasal passages or mild mucus membrane irritation after administration.  Most reported side effects are mild and transient.

  • Headaches

  • Nausea

  • Vomiting

  • Drowsiness

  • Hair Loss (Increased BDNF levels can promote hair loss in patients prone to baldness) 

Semax Administration

Semax is adminstered via nasal spray. 

Dosing:  2 Week Cycle

Days 1-4:  One spray in each nostril / 1 x daily /  Morning on an empty stomach

Days 5-14:  One spray in each nostril / 2 x daily / Morning and Afternoon on an empty stomach

**4 week break between Semax cycle

** Recommended to start Semax initially on its own and not in combination with other nootropics

Semax Cognitive Healing Combos

Cognitive Enhancement Combos​​

  • NAD+ / Semax (2 cycles) / Selank (2 cycles)

  • NAD+ 3month Cognitive Enhancement Program / Semax (2 cycles) / Selank (2 cycles)

Hormone Replacement Therapy

  • Semax can be used in conjunction with HRT, TRT, Sermorelin HGH Peptide, and other Peptide Therapies

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Research and References

1.  Semax, an ACTH (4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.  KO Eremin, VS Kudrin, P Saransaari, SS Oja… - … Research, 2005 - Springer

2.  Synthetic acth analogue semax displays nootropic‐like activity in humans.  AYA Kaplan, AG Kochetova… - … Research …, 1996 - Wiley Online Library

3.  Experimental substantiation of application of Semax as a modulator of immune reaction on the model of “social” stress.  MA Samotrueva, AL Yasenyavskaya… - Bulletin of Experimental …, 2019 - Springer

4.  Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.  VG Dmitrieva, OV Povarova, VI Skvortsova… - Cellular and molecular …, 2010 - Springer

 5.  Effects of Semax on dopaminergic and serotoninergic systems of the brain.  KO Eremin, VS Kudrin… - Doklady Biological …, 2004 -

6.  Semax, an analog of ACTH (4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.  OV Dolotov, EA Karpenko, LS Inozemtseva… - Brain research, 2006 - Elsevier

7.  The efficacy of semax in the tretament of patients at different stages of ischemic stroke.  EI Gusev, MY Martynov, EV Kostenko… - Zhurnal Nevrologii i …, 2018 -

8.  Semax, an ACTH (4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.  KO Eremin, VS Kudrin, P Saransaari, SS Oja… - … Research, 2005 - Springer

9.  Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency.  EI Gusev, VI Skvortsova… - Zhurnal Nevrologii I …, 2005 -

10.  Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke

NF Miasoedova, VI Skvortsova… - Zhurnal nevrologii i …, 1999 -

11.  Nootropic and analgesic effects of Semax following different routes of administration

DM Manchenko, G NIu, NG Levitskaia… - … zhurnal imeni IM …, 2010 -

12.  Influence of semax on the emotional state of white rats in the norm and against the background of cholecystokinin-tetrapeptide action.  NG Levitskaya, DA Vilenskii, EA Sebentsova… - Biology Bulletin, 2010 - Springer

13.  Kinetics of semax penetration into the brain and blood of rats after its intranasal administration.  KV Shevchenko, IY Nagaev, LY Alfeeva… - Russian Journal of …, 2006 -

14.  The Heptapeptide SEMAX stimulates BDNF Expression in Different Areas of the Rat Brain in vivo

OV Dolotov, TS Seredenina… - Doklady Biological …, 2003 -

15.  Investigation of the spectrum of physiological activities of the heptapeptide semax, an ACTH4–10 analogue.  NG Levitskaya, NY Glazova, EA Sebentsova… - Neurochemical …, 2008 -

16.  Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action

17.  Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain‐derived neurotrophic factor protein in rat basal forebrain.  OV Dolotov, EA Karpenko… - Journal of …, 2006 - Wiley Online Library

18.  The neuroprotective effects of Semax in conditions of MPTP-induced lesions of the brain dopaminergic system.  NG Levitskaya, EA Sebentsova, LA Andreeva… - Neuroscience and …, 2004 - Springer

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