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BPC-157 Peptide
BPC-157 Peptide
BPC-157 peptide is a 15 amino acid partial sequence of body protection compound (BPC) that was discovered in and isolated from human gastric juices. It has been demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments.
BPC-157 naturally occurs in our gastric juices in the gut and accelerates the repair and renewal of the intestinal tract. Since our intestines are under a lot of pressure and constantly working to repair damage, BPC 157 does a fantastic job of keeping everything running smoothly by regenerating cells of intestine walls and endothelium, preventing ulcers, stabilizing microbiome, and controlling blood vessel functioning.
BPC-157 interacts directly with Nitric Oxide (NO) pathway, regulating blood vessel functioning, but also promoting key growth factors. The primary mechanism of NO mediated wound healing is the formation of new blood vessels in a process called angiogenic repair. That means that more oxygen and energy can be delivered to injured spot to increase healing and recovery. BPC-157 promotes angiogenesis and the production of angiogenic cytokines like VEGF, TGF-b, and FGF. BPC 157 upregulates the Anti-Inflammatory Gene Transcription Factor, and Growth Hormone receptors, all leading to better systemic repair response.
BPC-157 also stimulates the growth and spread of fibroblasts, which are vital for the formation of a structural protein of your skin, bones, and connective tissue, called collagen.
BPC-157 Benefits
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Eliminate joint pain
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Promote accelerated healing of joints, tendon, muscle, and ligaments.
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Promote healing of GI disorders
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Improved digestive health
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Increased collagen production and healthy skin
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Increased Growth Hormone receptors in tissue
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Promotes healing of GI tract function
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Heals Mitochondrial damage
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Improved immune response to allergens and viruses
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Accelerated recovery from sports and exercise
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Reduces inflammation in autoimmune conditions like rheumatoid arthritis.
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Protection of cardiovascular system
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Protects endothelium and formation of scar tissue
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Reduced drug-induced damage on body
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Promotes angiogenesis for overall improved body repair and wound healing
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Improved mental health by modulating serotonergic and dopaminergic systems in the brain.
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BPC 157 Administration
BPC-157 Oral (Capsules)
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Dosing: 500mcg capsule administered one to two times daily orally on an empty stomach.
BPC-157 Injectable
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Dosing (10mg): 350mcg injection / 1 x daily / Subcutaneous injection / 4 Weeks
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Dosing (20mg): 350mcg injection / 2 x daily / Subcutaneous injection / 4 Weeks
BPC-157 Cycle Frequency
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3 Months On cycle / 1 Month Off cycle
BPC-157 Combo protocols:
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Wolverine Blend: BPC-157 (350mg) / TB500 (350mcg)
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GLOW Blend: BPC-157 (500mcg) / TB500 (500mcg) / GHK-Cu (2.5mg)
Disclaimer:
Individual results vary. Best results obtained with combination of a healthy diet and lifestyle . These products nor the ingredients have been approved or endorsed by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions. These are compounded by a US compounding pharmacy that provides these for physician prescribed patient-specific use only. You should consult a licensed health care professional before starting any peptide, supplement, dietary, or exercise program. Products not recommended if you are pregnant or breast feeding.
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BPC-157 Peptide Therapy FAQ
How is BPC-157 administered?
BPC-157 is available for both oral and subcutaneous injection. Oral administration is recommended if gut health is primary treatment concern. Subcutaneous injection is recommended for systemic healing and tendon/ligament support. Our clinical team will assist you in what administration method is best for your treatment concerns. Patients have reported positive results with both oral and injectable administration.
What are the potential benefits of BPC-157?
Potential benefits include support for tissue repair, recovery from musculoskeletal injuries, gastrointestinal health, inflammatory regulation, and cellular protection. BPC-157 has been researched for supporting gut health issues, tendon and ligament injuries, muscle tears, joint issues, post surgical recovery, wound healing, and chronic inflammation. This makes BPC-157 popular among athletes and individuals recovering from injuries.
Does BPC-157 help with tendon and ligament injuries?
BPC-157 is being investigated for its potential role in supporting tendon and ligament recovery through pathways involved in angiogenesis, fibroblast activity, collagen remodeling and inflammatory regulation. Preclinical studies have reported improvements in tendon and ligament healing.
Can BPC-157 help with muscle recovery?
BPC-157 is being investigated for its potential role in tissue recovery and cellular repair. Anecdotal evidence and patient results have shown positive results in supporting muscle recovery.
Is BPC-157 used for gut health?
BPC-157 has been investigated for potential effects on gastrointestinal tissues and inflammatory processes. Research has generated interest in its possible role in gastrointestinal health, but evidence in humans is limited. BPC-157 should not be represented as an established treatment for gastrointestinal diseases.
Does BPC-157 reduce inflammation?
Preclinical studies suggest that BPC-157 may influence inflammatory and tissue-repair pathways. However, whether these effects translate into meaningful clinical benefits in humans has not been established through large, well-controlled clinical trials.
Is BPC-157 FDA approved?
No. BPC-157 is not an FDA-approved drug. Patients are recommended to use BPC-157 and all peptides only under the guidance of a physician through a licensed medical facility like at Age Management of West Michigan.
Is BPC-157 safe and what are the side effects of BPC-157?
The long-term safety of BPC-157 has not been established, but no serious side effects and drug interactions have been documented. Minor side effects of irritation at injections site have been documented. Anyone considering BPC-157 should discuss potential risks, medical history, medications, and treatment alternatives with a qualified healthcare professional. Peptides should only be utilized through physician prescribed programs with peptides sourced from US licensed compounding pharmacies in the US.
How long does BPC-157 take to work?
Results vary depending on the individual patient variables and conditions that are being treated. Most patients start reporting results as early as 2 weeks into treatment. Age Management of West Michigan recommends a 3 month treatment cycle for optimal results.
Who may be a candidate for BPC-157 peptide therapy?
A healthcare professional should determine whether BPC-157 peptide therapy is appropriate for an individual. All peptide treatments should be physician prescribed and a complete evaluation that may include medical history, current medications, health goals, existing conditions, and available evidence regarding potential benefits and risks.
Who should not use BPC-157?
BPC-157 is not recommended for individuals that have a current cancer malignancy, chronic liver or kidney disease, pregnant or breast feeding. A healthcare professional should determine whether BPC_157 peptide therapy is appropriate for an individual. All peptide treatments should be physician prescribed and a complete evaluation that may include medical history, current medications, health goals, existing conditions, and available evidence regarding potential benefits and risks.
Can BPC-157 be combined or stacked with other therapies?
Yes, BPC-157 has been successfully combined with other peptide therapies and hormone replacement therapy. BPC-157 is most commonly combined with TB500 in the wolverine peptide blend and also with GHK-Cu in the GLOW peptide blend.
Is BPC-157 legal to buy?
Yes. BPC-157 peptide is recommended to only be purchased through a licensed medical facility like Age Management of West Michigan and by physician prescription.
Where can I get BPC-157 peptide therapy in Grand Rapids, Michigan?
Individuals interested in BPC-157 should seek a medical evaluation from a qualified healthcare professional rather than purchasing peptide products from an unverified online source. Age Management of West Michigan provides physician-guided evaluation of peptide therapy options in Grand Rapids, MI and can discuss whether peptide therapy may be appropriate based on an individual's health goals and medical history.
Is BPC-157 right for me?
BPC-157 may be of interest to individuals exploring emerging peptide therapies for recovery, tissue health, or gastrointestinal wellness. A healthcare professional should determine whether BPC-157 peptide therapy is appropriate for an individual. All peptide treatments should be physician prescribed and a complete evaluation that may include medical history, current medications, health goals, existing conditions, and available evidence regarding potential benefits and risks.
Research and References
1. Sikiric P., Seiwerth S., Mise S., Staresinic M., Bedekovic V., Zarkovic N., Borovic S., Gjurasin M., Boban-Blagaic A., Batelja L., Rucman R., Anic T. Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice. Burns. 2003;29(4):323–334.
2. Seiwerth S, Sikiric P, Grabarevic Z. BPC 157’s effect on healing. Journal of physiology, Paris. ; 91(3-5):173-8.
3. Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, et al. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015;9:2485–2499. doi: 10.2147/DDDT.S82030.
4. Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation. Journal of orthopaedicresearch : official publication of the Orthopaedic Research Society. 2006; 24(5):982-9.
5. Staresinic M., Sebecic B., Patrlj L., Jadrijevic S., Suknaic S., Perovic D., Aralica G., Zarkovic N., Borovic S., Srdjak M., et al. Gastric pentadecapeptide BPC 157 accelerated healing of transected rat Achilles tendon and in vitro stimulates tenocytes growth. J. Orhtop. Res. 2003;21:976–983. doi: 10.1016/S0736-0266(03)00110-4.
6. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of applied physiology (Bethesda, Md. : 1985). 2011; 110(3):774-80.
7. Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077. Published 2014 Nov 19. doi:10.3390/molecules191119066.
8. Zoricic I., Sikiric P., Seiwerth S. Pentadecapeptide BPC-157 beneficially influences the healing of colon-colon anastamoses in rats. In: Mozsik G., Nagy L., Par A., Rainsford K., editors. Cell Injury and Protection in the Gastrointestinal Tract. From Basic Science to Clinical Perspectives. Kluwer Academic Publishers; Dodrecht, The Netherlands: 1997. pp. 249–258.
9. Sebecić B, Nikolić V, Sikirić P. Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation. Bone. 1999; 24(3):195-202.
10. Xue XC, Wu YJ, Gao MT. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World journal of gastroenterology. 2004; 10(7):1032-6.
11. Sikiric P., Petek M., Rucman R., Seiwerth S., Grabarević Z., Rotkvić I., Jagić V., Turković B., Mildner B., Duvnjak M., et al. The significance of the gastroprotective effect of body protection compound (BPC): Modulation by different procedures. Acta Physiol. Hung. 1992;80:89–98.
12. Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, et al. BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Curr Pharm Des. 2018;24(18):1972–1989. doi: 10.2174/1381612824666180712110447.
13. Sikiric P, Seiwerth S, Rucman R. Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution? Current pharmaceutical design. 2017; 23(27):4012-4028.
14. Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2009; 60 Suppl 7:191-6.
15. Sikiric P, Seiwerth S, Rucman R. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Current neuropharmacology. 2016; 14(8):857-865.
16. BobanBlagaic A, Blagaic V, Mirt M. Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats. European journal of pharmacology. 2005; 512(2-3):173-9.