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NAD+

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

DNA

NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a prevalent electron transporter, coenzyme, and signaling molecule found in all cells of the body and is vital for cell function and viability.

NAD+ is essential for the metabolic processes and reactions that occur within our cells, as well as brain rejuvenation.  All cellular events occurring within our bodies require the presence of NAD+.   

 

Depletion of NAD+ has been associated with the onset of age related illness and disease, increased DNA damage, and mitochondrial dysfunction.

NAD+ is most commonly utilized by patients for its anti-aging benefits 
that both increase cognitive function and prevent cognitive decline.

NAD+ Benefits

  • Improved Cognitive Functions:  Improved performance in mental clarity, focus, memory, and improved mood.​

  • Prevents Cognitive Decline and neurological cellular aging

  • Protect against age related cognitive diseases like Alzheimer's and Parkinson's.

  • Promote healing of GI disorders and improves overall digestive health

  • Increased energy and metabolism

  • Enhances Mitochondrial function and repairs Mitochondrial damage

  • Improves hearing and eyesight function

  • Improved cardiovascular health

  • Addiction support:  Decreases cravings and withdrawal symptoms

  • Improved athletic performance and recovery from sports and exercise

  • Improved sleep quality

  • Anti-Aging Properties:  Slows the overall aging process by supporting DNA repair and cellular signaling.

NAD+ Administration

NAD+ dosing is 50mg daily administered 5 times weekly (5 days on / 2 off) by IM injection.  NAD+ is administered in a 3 month cycle.

NAD+ 3 month Cognitive Enhancement Protocol

Disclaimer: 

Individual results vary.  Best results obtained with combination of a healthy diet and lifestyle .   These products nor the ingredients have been approved or endorsed by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.   Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions.  These are compounded for human use by a US 503A compounding pharmacy that provides these on patient-specific use as a dietary supplement.   You should consult a licensed health care professional before starting any supplement, dietary, or exercise program.  Products not recommended if you are pregnant or breast feeding.

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Research and References

1.  Katsyuba, E., Romani, M., Hofer, D. et al. NAD+ homeostasis in health and disease. Nat Metab 2, 9–31 (2020). https://doi.org/10.1038/s42255-019-0161-5

2.  Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur.  Age-related NAD+.  Experimental Gerontology  Volume 134, June 2020, 110888

3.  Covarrubias, A.J., Perrone, R., Grozio, A. et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 22, 119–141 (2021). https://doi.org/10.1038/s41580-020-00313-x

4.  Hassina Massudi, Ross Grant, Gilles J Guillemin & Nady Braidy (2012) NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns, Redox Report, 17:1, 28-46, DOI: 10.1179/1351000212Y.0000000001

5.  Peter Belenky, Katrina L. Bogan, Charles Brenner. NAD+ metabolism in health and disease

Trends in Biochemical Sciences.  Volume 32, Issue 1, January 2007, Pages 12-19

6.  Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris , Ravinder Reddy, Zoltan Patay, Joseph Baur 10, Puneet Bagga.  Role of NAD+ in regulating cellular and metabolic signaling pathways.  Molecular Metabolism  Volume 49, July 2021, 101195.

7.  Xie, N., Zhang, L., Gao, W. et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Sig Transduct Target Ther 5, 227 (2020). https://doi.org/10.1038/s41392-020-00311-7.

8.  NAD+ in aging, metabolism, and neurodegeneration.  Eric Verdin.  SCIENCE.  4 Dec 2015.  Vol 350, Issue 6265  pp. 1208-1213.

9.  Riekelt H. Houtkooper, Carles Cantó, Ronald J. Wanders, Johan Auwerx, The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways, Endocrine Reviews, Volume 31, Issue 2, 1 April 2010, Pages 194–223, https://doi.org/10.1210/er.2009-0026

10.  Goody, M.F., Henry, C.A. A need for NAD+ in muscle development, homeostasis, and aging. Skeletal Muscle 8, 9 (2018). https://doi.org/10.1186/s13395-018-0154-1

11.  Imai, Si., Guarente, L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis 2, 16017 (2016). https://doi.org/10.1038/npjamd.2016.17

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