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NAD+

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

DNA

NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a prevalent electron transporter, coenzyme, and signaling molecule found in all cells of the body and is vital for cell function and viability.

NAD+ is essential for the metabolic processes and reactions that occur within our cells, as well as brain rejuvenation.  All cellular events occurring within our bodies require the presence of NAD+.   

 

Depletion of NAD+ has been associated with the onset of age related illness and disease, increased DNA damage, and mitochondrial dysfunction.

NAD+ is most commonly utilized by patients for its anti-aging benefits 
that both increase cognitive function and prevent cognitive decline.

NAD+ Benefits

  • Improved Cognitive Functions:  Improved performance in mental clarity, focus, memory, and improved mood.​

  • Prevents Cognitive Decline and neurological cellular aging

  • Protect against age related cognitive diseases like Alzheimer's and Parkinson's.

  • Promote healing of GI disorders and improves overall digestive health

  • Increased energy and metabolism

  • Enhances Mitochondrial function and repairs Mitochondrial damage

  • Improves hearing and eyesight function

  • Improved cardiovascular health

  • Addiction support:  Decreases cravings and withdrawal symptoms

  • Improved athletic performance and recovery from sports and exercise

  • Improved sleep quality

  • Anti-Aging Properties:  Slows the overall aging process by supporting DNA repair and cellular signaling.

NAD+ Administration

NAD+ dosing is 50mg  administered two to three times weekly by IM injection.  NAD+ is administered in a 3 month cycle.

NAD+ Peptide Combo Healing Therapies

Regenerative Combo (Muscle/ Joints / Cartilage repair)​​

  • NAD+ and BPC 157:  12 week cycle

  • NAD+, BPC 157, and AOD9604:  12 week cycle

Hormone Replacement Therapy

  • NAD+ can be used in conjunction with HRT, TRT, Sermorelin HGH Peptide, and other Peptide Therapies

NAD+ 3 month Cognitive Enhancement Program

  • NAD+ (3 month cycle)

  • Mitocore supplement

  • LENS Neurofeedback (1 session weekly) 

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Research and References

1.  Katsyuba, E., Romani, M., Hofer, D. et al. NAD+ homeostasis in health and disease. Nat Metab 2, 9–31 (2020). https://doi.org/10.1038/s42255-019-0161-5

2.  Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur.  Age-related NAD+.  Experimental Gerontology  Volume 134, June 2020, 110888

3.  Covarrubias, A.J., Perrone, R., Grozio, A. et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 22, 119–141 (2021). https://doi.org/10.1038/s41580-020-00313-x

4.  Hassina Massudi, Ross Grant, Gilles J Guillemin & Nady Braidy (2012) NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns, Redox Report, 17:1, 28-46, DOI: 10.1179/1351000212Y.0000000001

5.  Peter Belenky, Katrina L. Bogan, Charles Brenner. NAD+ metabolism in health and disease

Trends in Biochemical Sciences.  Volume 32, Issue 1, January 2007, Pages 12-19

6.  Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris , Ravinder Reddy, Zoltan Patay, Joseph Baur 10, Puneet Bagga.  Role of NAD+ in regulating cellular and metabolic signaling pathways.  Molecular Metabolism  Volume 49, July 2021, 101195.

7.  Xie, N., Zhang, L., Gao, W. et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Sig Transduct Target Ther 5, 227 (2020). https://doi.org/10.1038/s41392-020-00311-7.

8.  NAD+ in aging, metabolism, and neurodegeneration.  Eric Verdin.  SCIENCE.  4 Dec 2015.  Vol 350, Issue 6265  pp. 1208-1213.

9.  Riekelt H. Houtkooper, Carles Cantó, Ronald J. Wanders, Johan Auwerx, The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways, Endocrine Reviews, Volume 31, Issue 2, 1 April 2010, Pages 194–223, https://doi.org/10.1210/er.2009-0026

10.  Goody, M.F., Henry, C.A. A need for NAD+ in muscle development, homeostasis, and aging. Skeletal Muscle 8, 9 (2018). https://doi.org/10.1186/s13395-018-0154-1

11.  Imai, Si., Guarente, L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis 2, 16017 (2016). https://doi.org/10.1038/npjamd.2016.17

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