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NAD+ (Nicotinamide Adenine Dinucleotide) is a prevalent electron transporter, coenzyme, and signaling molecule found in all cells of the body and is vital for cell function and viability.
NAD+ is essential for the metabolic processes and reactions that occur within our cells, as well as brain rejuvenation. All cellular events occurring within our bodies require the presence of NAD+.
Depletion of NAD+ has been associated with the onset of age related illness and disease, increased DNA damage, and mitochondrial dysfunction.
NAD+ is most commonly utilized by patients for its anti-aging benefits
that both increase cognitive function and prevent cognitive decline.
Improved Cognitive Functions: Improved performance in mental clarity, focus, memory, and improved mood.
Prevents Cognitive Decline and neurological cellular aging
Protect against age related cognitive diseases like Alzheimer's and Parkinson's.
Promote healing of GI disorders and improves overall digestive health
Increased energy and metabolism
Enhances Mitochondrial function and repairs Mitochondrial damage
Improves hearing and eyesight function
Improved cardiovascular health
Addiction support: Decreases cravings and withdrawal symptoms
Improved athletic performance and recovery from sports and exercise
Improved sleep quality
Anti-Aging Properties: Slows the overall aging process by supporting DNA repair and cellular signaling.
NAD+ risks and side effects
There are no current documented side effects or medication interactions.
NAD+ dosing is 50mg administered two to three times weekly by IM injection. NAD+ is administered in a 3 month cycle.
NAD+ Peptide Combo Healing Therapies
Regenerative Combo (Muscle/ Joints / Cartilage repair)
NAD+ and BPC 157: 12 week cycle
NAD+, BPC 157, and AOD9604: 12 week cycle
Hormone Replacement Therapy
NAD+ can be used in conjunction with HRT, TRT, Sermorelin HGH Peptide, and other Peptide Therapies
NAD+ 3 month Cognitive Enhancement Program
NAD+ (3 month cycle)
LENS Neurofeedback (1 session weekly)
**Semax and can be added to program
Research and References
1. Katsyuba, E., Romani, M., Hofer, D. et al. NAD+ homeostasis in health and disease. Nat Metab 2, 9–31 (2020). https://doi.org/10.1038/s42255-019-0161-5
2. Melanie R. McReynolds, Karthikeyani Chellappa, Joseph A. Baur. Age-related NAD+. Experimental Gerontology Volume 134, June 2020, 110888
3. Covarrubias, A.J., Perrone, R., Grozio, A. et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol 22, 119–141 (2021). https://doi.org/10.1038/s41580-020-00313-x
4. Hassina Massudi, Ross Grant, Gilles J Guillemin & Nady Braidy (2012) NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns, Redox Report, 17:1, 28-46, DOI: 10.1179/1351000212Y.0000000001
5. Peter Belenky, Katrina L. Bogan, Charles Brenner. NAD+ metabolism in health and disease
Trends in Biochemical Sciences. Volume 32, Issue 1, January 2007, Pages 12-19
6. Sara Amjad, Sabah Nisar, Ajaz A. Bhat, Ab Rauf Shah, Michael P. Frenneaux, Khalid Fakhro, Mohammad Haris , Ravinder Reddy, Zoltan Patay, Joseph Baur 10, Puneet Bagga. Role of NAD+ in regulating cellular and metabolic signaling pathways. Molecular Metabolism Volume 49, July 2021, 101195.
7. Xie, N., Zhang, L., Gao, W. et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Sig Transduct Target Ther 5, 227 (2020). https://doi.org/10.1038/s41392-020-00311-7.
8. NAD+ in aging, metabolism, and neurodegeneration. Eric Verdin. SCIENCE. 4 Dec 2015. Vol 350, Issue 6265 pp. 1208-1213.
9. Riekelt H. Houtkooper, Carles Cantó, Ronald J. Wanders, Johan Auwerx, The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways, Endocrine Reviews, Volume 31, Issue 2, 1 April 2010, Pages 194–223, https://doi.org/10.1210/er.2009-0026
10. Goody, M.F., Henry, C.A. A need for NAD+ in muscle development, homeostasis, and aging. Skeletal Muscle 8, 9 (2018). https://doi.org/10.1186/s13395-018-0154-1
11. Imai, Si., Guarente, L. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis 2, 16017 (2016). https://doi.org/10.1038/npjamd.2016.17