top of page

BPC 157 / Body Protecting Compound

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

Stretching
Women Weight Loss
Bloodflow

BPC 157 Peptide

BPC 157 peptide is a 15 amino acid partial sequence of body protection compound (BPC) that was discovered in and isolated from human gastric juices.  It has been demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments.

 

BPC 157 naturally occurs in our gastric juices in the gut and accelerates the repair and renewal of the intestinal tract. Since our intestines are under a lot of pressure and constantly working to repair damage, BPC 157 does a fantastic job of keeping everything running smoothly by regenerating cells of intestine walls and endothelium, preventing ulcers, stabilizing microbiome, and controlling blood vessel functioning.

 

BPC 157 interacts directly with Nitric Oxide (NO) pathway, regulating blood vessel functioning, but also promoting key growth factors. The primary mechanism of NO mediated wound healing is the formation of new blood vessels in a process called angiogenic repair. That means that more oxygen and energy can be delivered to injured spot to increase healing and recovery. BPC 157 promotes angiogenesis and the production of angiogenic cytokines like VEGF, TGF-b, and FGF.  BPC 157 upregulates the Anti-Inflammatory Gene Transcription Factor, and Growth Hormone receptors, all leading to better systemic repair response. 

​

BPC 157 also stimulates the growth and spread of fibroblasts, which are vital for the formation of a structural protein of your skin, bones, and connective tissue, called collagen.

BPC 157 Benefits

  • Eliminate joint pain​

  • Promote accelerated healing of joints, tendon, muscle, and ligaments.

  • Promote healing of GI disorders

  • Improved digestive health

  • Increased collagen production and healthy skin

  • Increased Growth Hormone receptors in tissue

  • Promotes healing of GI tract function

  • Heals Mitochondrial damage

  • Improved immune response to allergens and viruses

  • Accelerated recovery from sports and exercise

  • Reduces inflammation in autoimmune conditions like rheumatoid arthritis.

  • Protection of cardiovascular system

  • Protects endothelium and formation of scar tissue

  • Reduced drug-induced damage on body

  • Promotes angiogenesis for overall improved body repair and wound healing

  • Improved mental health by modulating serotonergic and dopaminergic systems in the brain.

BPC 157 Administration

BPC dosing is 500mcg administered one to two times daily orally on an empty stomach.

BPC 157 Combo Healing Therapies

Regenerative Combo (Muscle/ Joints / Cartilage repair)​

  • BPC 157 / KPV / TB500 / AOD9604 / Follistatin344 for up to 3 month cycle.

Hormone Replacement Therapy

  • BPC 157 can be used in conjunction with BHRT, TRT, Sermorelin HGH Peptide, and other Peptide Therapies

Disclaimer: 

Individual results vary.  Best results obtained with combination of a healthy diet and lifestyle .   These products nor the ingredients have been approved or endorsed by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.   Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions.  These are compounded for human use by a US 503A compounding pharmacy that provides these on patient-specific use as a dietary supplement.   You should consult a licensed health care professional before starting any supplement, dietary, or exercise program.  Products not recommended if you are pregnant or breast feeding.

doctor-patient-talking.jpg
Schedule your FREE consultation!

616.808.2695

Research and References

1.  Sikiric P., Seiwerth S., Mise S., Staresinic M., Bedekovic V., Zarkovic N., Borovic S., Gjurasin M., Boban-Blagaic A., Batelja L., Rucman R., Anic T. Corticosteroid-impairment of healing and gastric pentadecapeptide BPC-157 creams in burned mice. Burns. 2003;29(4):323–334. 

2. Seiwerth S, Sikiric P, Grabarevic Z. BPC 157’s effect on healing. Journal of physiology, Paris. ; 91(3-5):173-8.

3.  Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, et al. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015;9:2485–2499. doi: 10.2147/DDDT.S82030.

4.  Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P. Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: Promoted tendon-to-bone healing and opposed corticosteroid aggravation. Journal of orthopaedicresearch : official publication of the Orthopaedic Research Society. 2006; 24(5):982-9.

5.  Staresinic M., Sebecic B., Patrlj L., Jadrijevic S., Suknaic S., Perovic D., Aralica G., Zarkovic N., Borovic S., Srdjak M., et al. Gastric pentadecapeptide BPC 157 accelerated healing of transected rat Achilles tendon and in vitro stimulates tenocytes growth. J. Orhtop. Res. 2003;21:976–983. doi: 10.1016/S0736-0266(03)00110-4.

6.  Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of applied physiology (Bethesda, Md. : 1985). 2011; 110(3):774-80.

7.  Chang CH, Tsai WC, Hsu YH, Pang JH. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Molecules. 2014;19(11):19066–19077. Published 2014 Nov 19. doi:10.3390/molecules191119066.

8.  Zoricic I., Sikiric P., Seiwerth S. Pentadecapeptide BPC-157 beneficially influences the healing of colon-colon anastamoses in rats. In: Mozsik G., Nagy L., Par A., Rainsford K., editors. Cell Injury and Protection in the Gastrointestinal Tract. From Basic Science to Clinical Perspectives. Kluwer Academic Publishers; Dodrecht, The Netherlands: 1997. pp. 249–258.

9.  Sebecić B, Nikolić V, Sikirić P. Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation. Bone. 1999; 24(3):195-202.

10.  Xue XC, Wu YJ, Gao MT. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World journal of gastroenterology. 2004; 10(7):1032-6.

11.  Sikiric P., Petek M., Rucman R., Seiwerth S., Grabarević Z., Rotkvić I., Jagić V., Turković B., Mildner B., Duvnjak M., et al. The significance of the gastroprotective effect of body protection compound (BPC): Modulation by different procedures. Acta Physiol. Hung. 1992;80:89–98.

12.  Seiwerth S, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, et al. BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Curr Pharm Des. 2018;24(18):1972–1989. doi: 10.2174/1381612824666180712110447.

13.  Sikiric P, Seiwerth S, Rucman R. Stress in Gastrointestinal Tract and Stable Gastric Pentadecapeptide BPC 157. Finally, do we have a Solution? Current pharmaceutical design. 2017; 23(27):4012-4028.

14.  Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2009; 60 Suppl 7:191-6.

15.  Sikiric P, Seiwerth S, Rucman R. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Current neuropharmacology. 2016; 14(8):857-865.

16.  BobanBlagaic A, Blagaic V, Mirt M. Gastric pentadecapeptide BPC 157 effective against serotonin syndrome in rats. European journal of pharmacology. 2005; 512(2-3):173-9.

bottom of page