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D-SIP / Delta Sleep Inducing Peptide

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

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D-SIP Peptide

D-SIP or Delta Sleep Inducing Peptide is a nonapeptide that is recognized for its effects on promoting sleep.  D-SIP regulates sleep patterns by shortening the tie to fall asleep and extends the duration and quality of sleep.   D-SIP also has positive physiological benefits on the entire body with effects on the endocrine system, cardiovascular system, and neurotransmitter function.

How Does D-SIP Improve Sleep

D-SIP binds to receptors in multiple sites of the brain and brain stem that are associated with inducing sleep.  It increases the production of the neurotransmitter GABA that calms the brain and promotes relaxation and deeper sleep.   D-SIP also interacts with the hormones serotonin and melatonin which are involved in the induction of sleep and regulation of sleep patterns. 


Research on D-SIP has shown results of inducing sleep in patients with insomnia and improving the duration of time spent in slow wave restorative sleep patterns.  D-SIP is different from sleep medications because it does not change the tie or duration of sleep cycles which are important for a variety of physiological processes and anabolic hormone production. 

D-SIP does not change sleep stages, but increases the ability to go to sleep and stay into a deeper more restful sleep.

How Does D-SIP Improve Hormone Functions

D-SIP has an effect on neuroendocrine regulation and release of anterior pituitary hormones.  D-SIP influences the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), and growth hormone (GH).   Administration of D-SIP improves the regulation and production of hormones in these glands by increasing production of LH and GH, while decreasing the production of undesirable ones like cortisol and somatostatin.

D-SIP also plays a role in the regulation of circadian rhythms.


  • Improve Ability to Fall Asleep​

  • Improve Sleep Quality

  • Improve Sleep Patterns

  • Restore Circadian Rhythm Cycles

  • Modulate and Decrease Cortisol Production

  • Promote Growth Hormone (GH) and Luteinizing Hormone (LH) Release

  • Reduce Chronic Pain

  • Lower Blood Pressure

  • Lower Risk of Heart Disease

  • Decrease Anxiety and Depression

  • Increase Stress Resilience

  • Boost Cognitive Function

D-SIP Administration

D-SIP is administered by sublingual mouth spray.  Recommended starting dosage is 5 sprays under the tongue 30 minutes prior to sleep.  If needed administer another 3 to 5 sprays immediately before going to sleep.    


Individual results vary.  Best results obtained with combination of a healthy diet and lifestyle .   These products nor the ingredients have been approved or endorsed by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.   Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions.  These are compounded for human use by a US 503A compounding pharmacy that provides these on patient-specific use as a dietary supplement.   You should consult a licensed health care professional before starting any supplement, dietary, or exercise program.  Products not recommended if you are pregnant or breast feeding.

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Research and References
  1. Schoenenberger GA (1984). "Characterization, properties and multivariate functions of Delta-Sleep Inducing Peptide (DSIP)". European Neurology. 23 (5): 321–345. doi:10.1159/000115711PMID 6548966

  2. Iyer KS, McCann SM (November 1987). "Delta sleep inducing peptide (DSIP) stimulates the release of LH but not FSH via a hypothalamic site of action in the rat". Brain Research Bulletin. 19 (5): 535–538. doi:10.1016/0361-9230(87)90069-4PMID 3121137S2CID 7710977

  3. Koval'zon VM (1994). "[DSIP: the sleep peptide or an unknown hypothalamic hormone?]". Zhurnal Evoliutsionnoi Biokhimii I Fiziologii (in Russian). 30 (2): 310–319. PMID 7817664

  4. Sudakova KV, Coghlan JP, Kotov AV, Salieva RM, Polyntsev YV, Koplik EV (1995). "Delta-sleep inducing peptide sequels in mechanisms of resistance to emotional stress". Annals of the New York Academy of Sciences. 771 (1): 240–251. Bibcode:1995NYASA.771..240S

  5. Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II (2003). "Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia". Peptides. 24 (2): 307–311. doi:10.1016/S0196-9781(03)00040-8PMID 12668217

  6. Seifritz E, Muller M, Schonenberger G, Trachsel L, Hemmeter U, Hatzinger M, Ernst A, Moore P, Holsboer-Trachsler E (1995). "Human plasma DSIP decreases at the initiation of sleep at different circadian times". Peptides. 16 (8): 1475–1481. doi:10.1016/0196-9781(95)02027-6PMID 8745061S2CID 40634977

  7. Steiger A, Holsboer F (1997). "Neuropeptides and human sleep". Sleep. 20 (11): 1038–1052. PMID 9456470

  8. Westrin A, Ekman R, Traskman-Bendz L (1998). "High Delta Sleep-Inducing Peptide-Like Immunoreactivity in Plasma in Suicidal Patients with Major Depressive Disorder". Biological Psychiatry. 43 (10): 734–739. doi:10.1016/S0006-3223(97)00254-0

  9. Walleus H, Widerlöv E, Ekman R (1985). "Decreased concentrations of delta-sleep inducing peptide in plasma and cerebrospinal fluid from depressed patients". Nordic Journal of Psychiatry. 39: 63–67. doi:10.3109/08039488509101959

  10. Schneider-Helmert D (1986). "DSIP in Sleep Disturbances". Eur Neurol. 25 (2): 154–157. doi:10.1159/000116097PMID 3758119

  11. Schneider-Helmert D, Schoenenberger GA (1981). "The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep". Cellular and Molecular Life Sciences. 37 (9): 913–917. doi:10.1007/BF01971753PMID 7028502

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