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KPV Peptide

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

Knee Pain
GI Repair

KPV

KPV is a tri-peptide derived from a natural occurring hormone in the body called alpha-melanocyte-stimulating-hormone that exhibits anti-inflammatory, anti-microbial, and immunomodulating benefits.  KPV exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways. KPV can enter the cell and interact directly with inflammatory signaling molecules. It enters the nucleus of the cell and once it’s there, it can inhibit the inflammatory substances and molecules.  Research shows that KPV is effective in decreasing inflammation in the GI system by inhibiting proinflammatory cytokine mechanisms in both intestinal epithelial cells and immune cells.  This makes KPV very effective in treatment for a variety of inflammatory bowel diseases, Chron's disease, and colitis.

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KPV also expresses a strong anti-microbial and anti-fungal effect.  Research has shown a strong killing effect on both Staphylococcus aureus bacteria and the Candida Albicans.  KPV's effect of both decreasing inflammation in the GI system along with its strong anti-microbial and anti-fungal effects make it a perfect peptide treatment for healing and strengthening gastrointestinal system and immune system function.

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KPV Peptide Benefits

  • Anti-inflammatory:  Systemically and GI specific

  • Strengthen Immune System Function

  • Decrease Joint and Muscle Pain

  • Anti-Microbial Effects

  • Anti-Fungal Effect

  • Improved Gut Health 

  • Improve Skin Health

  • Accelerated Healing 

  • Protect against Nerve Damage

  • Protects against Stroke

  • Decrease Intestinal Inflammation

  • Decreased Scar Formation

KPV Peptide Administration

KPV Oral (Capsules)

  • Dosing:  500mcg capsule administered one to two times daily orally on an empty stomach.

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KPV Injectable

  • Dosing (10mg):  350mcg injection / 1 x daily /  Subcutaneous injection / 4 Weeks

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Disclaimer: 

Individual results vary.  Best results obtained with combination of a healthy diet and lifestyle .   These products nor the ingredients have been approved or endorsed by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.   Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions.  These are compounded by a US  compounding pharmacy that provides these for physician prescribed patient-specific use only.   You should consult a licensed health care professional before starting any peptide, supplement, dietary, or exercise program.  Products not recommended if you are pregnant or breast feeding.

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KPV Peptide Frequently Asked Questions

1. What is KPV peptide?

KPV is a naturally occurring tripeptide made up of three amino acids: lysine, proline, and valine. KPV is the C-terminal portion of alpha-melanocyte-stimulating hormone (α-MSH) and has been studied for its potential anti-inflammatory properties. Research has focused particularly on inflammatory signaling and intestinal health.

2. What are the potential benefits of KPV peptide?

Research suggests that KPV may have anti-inflammatory and tissue-supportive properties. Preclinical studies have investigated KPV's effects on inflammatory signaling, intestinal inflammation, and cellular responses. 

3. How does KPV peptide work?

KPV has been studied for its ability to influence inflammatory pathways, including NF-κB and MAP kinase signaling. Research also suggests that KPV can be transported into intestinal cells through the peptide transporter PepT1. These mechanisms may help explain the anti-inflammatory activity observed in experimental studies.

4. What is KPV peptide used for?

KPV is an emerging research peptide being investigated for its potential effects on inflammation, intestinal health, and other inflammatory processes. Research has included models of intestinal inflammation and inflammatory bowel disease. KPV is not currently an FDA-approved treatment for these conditions.

5. Can KPV peptide support gut health?

KPV has generated considerable research interest in gut health and intestinal inflammation. Patients have reported positive benefits with inflammatory gut symptoms.  Experimental studies have found that KPV can reduce inflammatory signaling and inflammatory changes in animal models of colitis. 

6. Is KPV peptide an anti-inflammatory peptide?

Yes, patients have reported a positive anti-inflammatory benefit with use of KPV peptide.  KPV is being studied as a potential anti-inflammatory peptide. Laboratory and animal research has demonstrated effects on inflammatory signaling, including pathways involving NF-κB and pro-inflammatory cytokines. These findings make KPV an area of interest in regenerative and peptide research, although human clinical evidence remains limited.

7. Is KPV peptide safe and what are the side effectss?

KPV has generally been well tolerated, with reported side effects being uncommon and mild. That said, the human safety database is small, and absence of reported problems in limited research is not the same as established long-term safety.  The human safety profile of KPV has not been adequately established.   Anyone considering KPV peptide should use only under physician prescribed guidance and discuss potential risks and benefits with a qualified healthcare professional.  

8. Can KPV peptide be combined with other peptides?

Yes, KPV can be used in conjunction with other peptides.  Combination peptide therapy should be approved and prescribed by qualified Age Management of West Michigan healthcare professional rather than based solely on online peptide protocols.

Research and References

1.  Luger TA, Brzoska T. alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis. 2007;66 Suppl 3(Suppl 3):iii52-iii55. doi:10.1136/ard.2007.079780

2.  Cutuli, M., Cristiani, S., Lipton, J. M., & Catania, A. (2000). Antimicrobial effects of alpha-MSH peptides. Journal of leukocyte biology, 67(2), 233–239. https://doi.org/10.1002/jlb.67.2.233.

3.  Dalmasso, G., et al. (2008). PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation. Gastroenterology, 134(1), 166–178. DOI: 10.1053/j.gastro.2007.10.026

4.  Klaus Kannengiesser, MD, Christian Maaser, MD, Jan Heidemann, MD, Andreas Luegering, MD, Matthias Ross, MD, Thomas Brzoska, PhD, Markus Bohm, MD, Thomas A. Luger, MD, Wolfram Domschke, MD, Torsten Kucharzik, MD, Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease, Inflammatory Bowel Diseases, Volume 14, Issue 3, 1 March 2008, Pages 324–331, https://doi.org/10.1002/ibd.20334.

5.  Brzoska T, Böhm M, Lügering A, Loser K, Luger TA. Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore. Adv Exp Med Biol. 2010;681:107-16. doi: 10.1007/978-1-4419-6354-3_8. PMID: 21222263.

6.  Luger TA, Bohm M. Are melanocortin peptides future therapeutics for cutaneous wound healing? Experimental Derm. 20 January 2019. https://doi.org/10.1111/exd.13887

7.  Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev. 2008 Aug;29(5):581-602. doi: 10.1210/er.2007-0027. Epub 2008 Jul 8. PMID: 18612139.

8.  Sarkar A, Sreenivasan Y, Manna SK 2003 α-Melanocyte-stimulating hormone induces cell death in mast cells: involvement of NF-κB. FEBS Lett 549:87–93.

9.  Redondo P, García-foncillas J, Okroujnov I, Bandrés E. Alpha-MSH regulates interleukin-10 expression by human keratinocytes. Arch Dermatol Res. 1998;290(8):425-8.

10.  Mehta D, Granstein R, D: Immunoregulatory Effects of Neuropeptides on Endothelial Cells: Relevance to Dermatological Disorders. Dermatology 2019;235:175-186. doi: 10.1159/000496538

11.  Sinha PS, Schiöth HB, Tatro JB. Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered alpha-MSH. Brain Res. 2004;1001(1-2):150-8

12.  Elliott R J, Szabo M, Wagner M J, Kemp E H, MacNeil S, Haycock J W. alpha‐Melanocyte‐stimulating hormone, MSH 11‐13 KPV and adrenocorticotropic hormone signaling in human keratinocyte cells. J Invest Dermatol 20041221010–1019.

13.  Van de meent H, Hamers FP, Lankhorst AJ, Joosten EA, Gispen WH. Beneficial effects of the melanocortin alpha-melanocyte-stimulating hormone on clinical and neurophysiological recovery after experimental spinal cord injury. Neurosurgery. 1997;40(1):122-30

14.  Abdel-malek ZA, Kadekaro AL, Kavanagh RJ, et al. Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity. FASEB J. 2006;20(9):1561-3

15.  Bohm M, Wolff I, Scholzen TE, et al. alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J Biol Chem. 2005;280(7):5795-802

16.  Lam C W, Getting S J. Melanocortin receptor type 3 as a potential target for anti‐inflammatory therapy. Curr Drug Targets Inflamm Allergy 20043311–315.

17.  Taylor AW, Yee DG, Nishida T, Namba K. Neuropeptide regulation of immunity. The immunosuppressive activity of alpha-melanocyte-stimulating hormone (alpha-MSH). Ann N Y Acad Sci. 2000;917:239-47

18.  3.  Rajora N, Boccoli G, Catania A, et al. α-MSH modulates experimental inflammatory bowel disease. Peptides. 1997;18:381–385.

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