PT 141 / Bremelanotide

Bremelanotide (PT 141) is a melanocortin receptor agonist agent that has demonstrated efficacy in improving both female Hypoactive Sexual Desire Disorder and male erectile disorder and hypoactive sexual dysfunction.  PT 141 works directly on brain and nervous system by activating melanocortin 1-5 (MC1-5R) receptors. 

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In females, PT 141 stimulates MC4R receptors involved in sexual arousal and response.   This stimulates the release of dopamine to brain areas that are involved in regulating the motivation and arousal of sexual behavior.   PT 141 has been shown in clinical trials to effectively treat HSDD (Hypoactive Sexual Desire Disorder) in both pre and post-menopausal women.  PT 141 has also shown in clinical trials to assist females in obtaining climax and obtaining a 50% increased satisfaction with sexual intercourse.

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In Males, PT 141 acts on MC3R and MC4R to help treat erectile dysfunction and increase sexual arousal.   PT 141 works on the central nervous system instead of the vascular system like most ED drugs that are PDE5 inhibitors.  Clinical studies showed that PT 141 increased erections in 80% of men who do not respond to Viagra or Cialis.