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TB500 (Thymosin Beta-4)

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

TB500 Peptide Therapy in Grand Rapids, MI

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TB500

TB500 is a synthetic fraction of the 43 amino acid protein thymosin beta-4. The main purpose of this peptide is to promote healing. The healing effects of TB500 have been observed in tendons, ligaments, muscles, skin, heart, and eyes. It aids in the quick healing of wounds by promoting new blood vessel and muscle fiber growth. It upregulates cell building proteins like actin and stimulates hair growth.

Thymosin is a hormone secreted from the thymus with the function to stimulate production of T cells in the immune system and assist in develop of B cells in the immune system to produce antibodies.  The main form of thymosin is thymosin beta-4 is an actin cell building protein.   Actin is a cell building protein with a primary role in protection, regeneration, and remodeling of damaged tissue.  After an injury is sustained in the body, it releases TB4 to protect damaged cells and tissues as well as reduce inflammation and microbial growth.  TB500 promotes angiogenesis (formation of new blood vessels) in the injured tissue to increase blood, nutrients, and growth factors.   TB500 decreases cytokines which decreases inflammation.

TB500 Benefits

  • Boost immune system function

  • Increase cellular repair and regenerative properties

  • Improve soft tissue repair:  Muscle, tendons, ligaments, and fascia

  • Promotes angiogenesis:  formation of new blood vessels

  • Improved recovery from sports and exercise

  • Decrease inflammation and cytokine production

  • Reduce scar tissue and adhesions

  • Improve Cardiovascular health

  • Improve liver health

  • Improve eye health

  • Improve brain health

  • Improve lung health

  • Promote nerve regeneration

  • Stabilize blood sugar

  • Reduce blood pressure

  • Promotes hair growth

TB500 Administration

TB500 Oral (Capsules)

  • Dosing:  500mcg capsule administered one to two times daily orally on an empty stomach.

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TB500 Injectable

  • Dosing (10mg):  350mcg injection / 1 x daily /  Subcutaneous injection / 4 Weeks

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TB500 Peptide combo protocols:

  • Wolverine Blend:  BPC-157 (350mg) / TB500 (350mcg) 

  • GLOW Blend:  BPC-157 (500mcg) / TB500 (500mcg) / GHK-Cu (2.5mg)

Disclaimer: 

Individual results vary.  Best results obtained with combination of a healthy diet and lifestyle .   These products nor the ingredients have been approved or endorsed by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.   Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions.  These are compounded by a US  compounding pharmacy that provides these for physician prescribed patient-specific use only.   You should consult a licensed health care professional before starting any peptide, supplement, dietary, or exercise program.  Products not recommended if you are pregnant or breast feeding.

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TB500 Peptide Therapy FAQ​

How is TB500 administered?

TB500 is available for both oral and subcutaneous injection.   Oral administration is recommended if gut health is primary treatment concern.   Subcutaneous injection is recommended for systemic healing, tendon/ligament support, and immune system support.  Our clinical team will assist you in what administration method is best for your treatment concerns.  Patients have reported positive results with both oral and injectable administration.

What are the potential benefits of TB500?

Potential benefits include support for tissue repair, recovery from musculoskeletal injuries, gastrointestinal health, inflammatory regulation, and cellular protection.   TB500 has been researched for supporting tendon and ligament injuries, muscle tears, joint issues, post surgical recovery, wound healing, and chronic inflammation.   This makes TB500 popular among athletes and individuals recovering from injuries.

Does TB500 help with tendon and ligament injuries?

TB500 is being investigated for its potential role in supporting tendon and ligament recovery through pathways involved in angiogenesis, fibroblast activity, collagen remodeling and inflammatory regulation. Preclinical studies have reported improvements in tendon and ligament healing.

Can TB500 help with muscle recovery?

TB500 is being investigated for its potential role in tissue recovery and cellular repair. Anecdotal evidence and patient results have shown positive results in supporting muscle recovery.  

Does TB500 reduce inflammation?

Preclinical studies suggest that TB500 may influence inflammatory and tissue-repair pathways. However, whether these effects translate into meaningful clinical benefits in humans has not been established through large, well-controlled clinical trials.

Is TB500 FDA approved?

No. TB500 is not an FDA-approved drug. Patients are recommended to use TB500 and all peptides only under the guidance of a physician through a licensed medical facility like at Age Management of West Michigan.  

Is TB500 safe and what are the side effects of TB500?

The long-term safety of TB500 has not been established, but no serious side effects and drug interactions have been documented.  Minor side effects of irritation at injections site have been documented.   Anyone considering TB500 should discuss potential risks, medical history, medications, and treatment alternatives with a qualified healthcare professional.  Peptides should only be utilized through physician prescribed programs with peptides sourced from US licensed compounding pharmacies in the US.

 

How long does TB500 take to work?

Results vary depending on the individual patient variables and conditions that are being treated.  Most patients start reporting results as early as 2 weeks into treatment.  Age Management of West Michigan recommends a 3 month treatment cycle for optimal results.

Who may be a candidate for TB500 peptide therapy?

A healthcare professional should determine whether TB500 peptide therapy is appropriate for an individual. All peptide treatments should be physician prescribed and a complete evaluation that may include medical history, current medications, health goals, existing conditions, and available evidence regarding potential benefits and risks.

Who should not use TB500?

TB500 is not recommended for individuals that have a current cancer malignancy, chronic liver or kidney disease, pregnant or breast feeding.  A healthcare professional should determine whether TB500 peptide therapy is appropriate for an individual. All peptide treatments should be physician prescribed and a complete evaluation that may include medical history, current medications, health goals, existing conditions, and available evidence regarding potential benefits and risks.

Can TB500 be combined or stacked with other therapies?

Yes, TB500 has been successfully combined with other peptide therapies and hormone replacement therapy.   TB500 is most commonly combined with BPC-157 in the wolverine peptide blend and also with BPC-157 and GHK-Cu in the GLOW peptide blend.

Is TB500 legal to buy?

Yes.  TB500 peptide is recommended to only be purchased through a licensed medical facility like Age Management of West Michigan and by physician prescription.  

Where can I get TB500 peptide therapy in Grand Rapids, Michigan?

Individuals interested in TB500 should seek a medical evaluation from a qualified healthcare professional rather than purchasing peptide products from an unverified online source. Age Management of West Michigan provides physician-guided evaluation of peptide therapy options in Grand Rapids, MI and can discuss whether peptide therapy may be appropriate based on an individual's health goals and medical history.

Is TB500 right for me?

TB500 may be of interest to individuals exploring emerging peptide therapies for recovery, tissue health, or gastrointestinal wellness. A healthcare professional should determine whether TB500 peptide therapy is appropriate for an individual. All peptide treatments should be physician prescribed and a complete evaluation that may include medical history, current medications, health goals, existing conditions, and available evidence regarding potential benefits and risks.

Research and References

  1. Reti R, Kwon E, Qiu P, Wheater M, Sosne G. Thymosin beta4 is cytoprotective in human gingival fibroblasts. European journal of oral sciences. 2008; 116(5):424-30. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18821984.

  2. Lee HR, Yoon SY, Kang HB. Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1. Immunology letters. 2009; 123(1):72-6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19369144.

  3. Low TL, Thurman GB, Chincarini C. Current status of thymosin research: evidence for the existence of a family of thymic factors that control T-cell maturation. Annals of the New York Academy of Sciences. 1979; 332:33-48. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/394636.

  4. Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I. Thymosin beta4 and cardiac repair. Annals of the New York Academy of Sciences. 2010; 1194:87-96. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20536454.

  5. Zhu J, Song J, Yu L. Safety and efficacy of autologous thymosin β4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study. Cytotherapy. 2016; 18(8):1037-42. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27288307.

  6. Kumar S, Gupta S. Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts. PloS one. 2011; 6(10):e26912. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22046407.

  7. Jiang Y, Han T, Zhang Z-G, et al. Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease. Chronic Diseases and Translational Medicine. 2017;3(3):165-168. doi:10.1016/j.cdtm.2017.06.003. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643779/.

  8. Philp D, Kleinman HK. Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Annals of the New York Academy of Sciences. 2010; 1194:81-6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20536453.

  9. Philp D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mechanisms of ageing and development. 2004; 125(2):113-5. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15037013.

  10. Malinda KM, Sidhu GS, Mani H. Thymosin beta4 accelerates wound healing. The Journal of investigative dermatology. 1999; 113(3):364-8. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10469335.

  11. Kleinman, H. K., & Sosne, G. (2016). Thymosin β4 Promotes Dermal Healing. Vitamins and hormones, 102, 251–275. https://doi.org/10.1016/bs.vh.2016.04.005.

  12. Morris DC, Cui Y, Cheung WL. A dose-response study of thymosin β4 for the treatment of acute stroke. Journal of the neurological sciences. 2014; 345(1-2):61-7. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25060418.

  13. Morris DC, Zhang ZG, Zhang J, Xiong Y, Zhang L, Chopp M. Treatment of neurological injury with thymosin β4. Annals of the New York Academy of Sciences. 2012; 1269:110-6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23045978.

  14. Henry Ford Health System. “Researchers propose novel new treatment of stroke, other neurological diseases.” ScienceDaily. ScienceDaily, 2 March 2015. Retrieved from https://www.sciencedaily.com/releases/2015/03/150302123301.htm.

  15. Philp, D., Nguyen, M., Scheremeta, B., St-Surin, S., Villa, A. M., Orgel, A., Kleinman, H. K., & Elkin, M. (2004). Thymosin beta4 increases hair growth by activation of hair follicle stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(2), 385–387. https://doi.org/10.1096/fj.03-0244fje.

  16. Gao, X. Y., Hou, F., Zhang, Z. P., Nuo, M. T., Liang, H., Cang, M., Wang, Z. G., Wang, X., Xu, T., Yan, L. Y., Guo, X. D., & Liu, D. J. (2016). Role of thymosin beta 4 in hair growth. Molecular genetics and genomics: MGG, 291(4), 1639–1646. https://doi.org/10.1007/s00438-016-1207-y.

  17. Dai, B., Sha, R. N., Yuan, J. L., & Liu, D. J. (2021). Multiple potential roles of thymosin β4 in the growth and development of hair follicles. Journal of cellular and molecular medicine, 25(3), 1350–1358. https://doi.org/10.1111/jcmm.16241.

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