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TB 500 (Thymosin Beta-4)

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

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TB500

TB-500 is a synthetic fraction of the 43 amino acid protein thymosin beta-4. The main purpose of this peptide is to promote healing. The healing effects of TB-500 have been observed in tendons, ligaments, muscles, skin, heart, and eyes. It aids in the quick healing of wounds by promoting new blood vessel and muscle fiber growth. It upregulates cell building proteins like actin and stimulates hair growth.

Thymosin is a hormone secreted from the thymus with the function to stimulate production of T cells in the immune system and assist in develop of B cells in the immune system to produce antibodies.  The main form of thymosin is thymosin beta-4 is an actin cell building protein.   Actin is a cell building protein with a primary role in protection, regeneration, and remodeling of damaged tissue.  After an injury is sustained in the body, it releases TB4 to protect damaged cells and tissues as well as reduce inflammation and microbial growth.  TB500 promotes angiogenesis (formation of new blood vessels) in the injured tissue to increase blood, nutrients, and growth factors.   TB500 decreases cytokines which decreases inflammation.

TB500 Benefits

  • Boost immune system function

  • Increase cellular repair and regenerative properties

  • Improve soft tissue repair:  Muscle, tendons, ligaments, and fascia

  • Promotes angiogenesis:  formation of new blood vessels

  • Improved recovery from sports and exercise

  • Decrease inflammation and cytokine production

  • Reduce scar tissue and adhesions

  • Improve Cardiovascular health

  • Improve liver health

  • Improve eye health

  • Improve brain health

  • Improve lung health

  • Promote nerve regeneration

  • Stabilize blood sugar

  • Reduce blood pressure

  • Promotes hair growth

TB500 Administration

TB500 dosing is 500mcg administered one to two times daily orally on an empty stomach.

TB500 Combo Healing Therapies

Regenerative Combo (Muscle/ Joints / Cartilage repair)

  • BPC 157 / KPV / AOD9604 / Follistatin344 for up to 3 month cycle.

Hormone Replacement Therapy

  • TB500 can be used in conjunction with BHRT, TRT, Sermorelin HGH Peptide, and other Peptide Therapies

Disclaimer: 

Individual results vary.  Best results obtained with combination of a healthy diet and lifestyle .   These products nor the ingredients have been approved or endorsed by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.   Homeopathic products have not been reviewed by the FDA for safety and effectiveness to diagnose, treat, cure, or prevent any disease or conditions.  These are compounded for human use by a US 503A compounding pharmacy that provides these on patient-specific use as a dietary supplement.   You should consult a licensed health care professional before starting any supplement, dietary, or exercise program.  Products not recommended if you are pregnant or breast feeding.

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Research and References
  1. Reti R, Kwon E, Qiu P, Wheater M, Sosne G. Thymosin beta4 is cytoprotective in human gingival fibroblasts. European journal of oral sciences. 2008; 116(5):424-30. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18821984.

  2. Lee HR, Yoon SY, Kang HB. Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1. Immunology letters. 2009; 123(1):72-6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/19369144.

  3. Low TL, Thurman GB, Chincarini C. Current status of thymosin research: evidence for the existence of a family of thymic factors that control T-cell maturation. Annals of the New York Academy of Sciences. 1979; 332:33-48. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/394636.

  4. Shrivastava S, Srivastava D, Olson EN, DiMaio JM, Bock-Marquette I. Thymosin beta4 and cardiac repair. Annals of the New York Academy of Sciences. 2010; 1194:87-96. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20536454.

  5. Zhu J, Song J, Yu L. Safety and efficacy of autologous thymosin β4 pre-treated endothelial progenitor cell transplantation in patients with acute ST segment elevation myocardial infarction: A pilot study. Cytotherapy. 2016; 18(8):1037-42. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/27288307.

  6. Kumar S, Gupta S. Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts. PloS one. 2011; 6(10):e26912. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22046407.

  7. Jiang Y, Han T, Zhang Z-G, et al. Potential role of thymosin beta 4 in the treatment of nonalcoholic fatty liver disease. Chronic Diseases and Translational Medicine. 2017;3(3):165-168. doi:10.1016/j.cdtm.2017.06.003. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643779/.

  8. Philp D, Kleinman HK. Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Annals of the New York Academy of Sciences. 2010; 1194:81-6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20536453.

  9. Philp D, Goldstein AL, Kleinman HK. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mechanisms of ageing and development. 2004; 125(2):113-5. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/15037013.

  10. Malinda KM, Sidhu GS, Mani H. Thymosin beta4 accelerates wound healing. The Journal of investigative dermatology. 1999; 113(3):364-8. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10469335.

  11. Kleinman, H. K., & Sosne, G. (2016). Thymosin β4 Promotes Dermal Healing. Vitamins and hormones, 102, 251–275. https://doi.org/10.1016/bs.vh.2016.04.005.

  12. Morris DC, Cui Y, Cheung WL. A dose-response study of thymosin β4 for the treatment of acute stroke. Journal of the neurological sciences. 2014; 345(1-2):61-7. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25060418.

  13. Morris DC, Zhang ZG, Zhang J, Xiong Y, Zhang L, Chopp M. Treatment of neurological injury with thymosin β4. Annals of the New York Academy of Sciences. 2012; 1269:110-6. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23045978.

  14. Henry Ford Health System. “Researchers propose novel new treatment of stroke, other neurological diseases.” ScienceDaily. ScienceDaily, 2 March 2015. Retrieved from https://www.sciencedaily.com/releases/2015/03/150302123301.htm.

  15. Philp, D., Nguyen, M., Scheremeta, B., St-Surin, S., Villa, A. M., Orgel, A., Kleinman, H. K., & Elkin, M. (2004). Thymosin beta4 increases hair growth by activation of hair follicle stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(2), 385–387. https://doi.org/10.1096/fj.03-0244fje.

  16. Gao, X. Y., Hou, F., Zhang, Z. P., Nuo, M. T., Liang, H., Cang, M., Wang, Z. G., Wang, X., Xu, T., Yan, L. Y., Guo, X. D., & Liu, D. J. (2016). Role of thymosin beta 4 in hair growth. Molecular genetics and genomics: MGG, 291(4), 1639–1646. https://doi.org/10.1007/s00438-016-1207-y.

  17. Dai, B., Sha, R. N., Yuan, J. L., & Liu, D. J. (2021). Multiple potential roles of thymosin β4 in the growth and development of hair follicles. Journal of cellular and molecular medicine, 25(3), 1350–1358. https://doi.org/10.1111/jcmm.16241.

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