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GI Microbiome Restore Program

Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

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Gut Microbiome and Microbiota

Gut bacteria are an essential component of the microbiota ecosystem in the human gut.   The human gut is home to ten times more bacteria than human cells.   These bacteria play an important role in many life sustaining activities such as utilization of essential nutrients, synthesizing of vitamins, digestion of cellulose and fibers, promoting of angiogenesis, and supporting enteric nerve function (Gut-Brain Axis).    These commensal bacteria contribute to the body's defense mechanisms by regulating homeostasis of the body's immune system.   The gut bacteria also support the body in a variety of other ways by regulating gut motility, transforming bile acids and steroids, metabolizing xenobiotic substances, absorbing minerals, and supporting on going detoxification by activating and destroying toxins, genotoxins, and mutagens.  

Influences on Gut Microbiota

The body's gut microbiota ecosystem can be influenced by several factors such as lifestyle, dietary habits, living environment, stress, age, illness, and use of antibiotics.  Studies show that long-term and short-term diets have one of the biggest influences on the composition and function of the gut microbiota in humans.   Microbiome composition can change considerably in just 24 hours of dietary changes.  

Gut microbiota ecosystem in the stomach and colon is distinctive and unique to individuals based on physiochemical conditions such as intestinal motility, pH value, redox conditions, nutrients, and the presence of an intact ileocaecal valve.

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Gut Bacteria and Immune System 

Majority of your immune system function occurs in the gut.   The gut resists pathogenic bacteria through two barriers, the mechanical and immune barrier.  The mechanical barrier consists of the intestinal lumen and mucosal lining.  The immune barrier consists of secretions of immunoglobulin A (IgA), intraepithelial lymphocytes, macrophages, neutrophils, natural killer cells, Peyer's plaques, and mesenteric lymph nodes.  Commensal bacteria support mechanical barrier by promoting the integrity of gut barriers.  Commensal gut bacterial mainly support the immune system by preventing the invasion and colonization of pathogenic bacteria through colonization resistance , production of lactate and short-chain fatty acids to reduce intestinal pH, and by producing toxic metabolites to inhibit the growth or kill potentially pathogenic bacteria.  Dysbiosis (Overabundance of pathogenic bad bacteria to good commensal bacteria) cause many diseases such as inflammatory bowel disease, obesity, diabetes, liver disease, chronic heart disease, neurological disease and decline, cancer, and overall inflammation.  Commensal gut bacteria are essential for a strong immune system.

The GI Microbiome Restore Program effectively restores commensal bacteria and restores homeostasis to the body's microbiota ecosystem in 12 weeks.

GI Microbiome Restore Program (12 Weeks)

Objectives of GI Microbiome Restore Program

  1. Restore commensal gut bacterial levels and build diversity of microbiota environment of key strain bacteria with probiotic and prebiotic supplements and foods.

  2. Restore microbiome balance by increasing Short Chain Fatty Acid (SCFA) and butyrate levels through dietary and lifestyle changes with the GI Microbiome Restore Diet.

  3. Remove immune triggers from diet that promote inflammation and pathogen bacteria / yeast overgrowth in the gut.

GI Microbiome Restore Diet

Real food diet of vegetables, fruit, and lean proteins to increase SCFA's and butyrate to restore healthy microbiome balance and promote growth of commensal bacteria.   

Probiotic and Prebiotic Supplementation

Monthly rotation of probiotic and prebiotic supplementation to increase commensal bacteria levels and diversity.

Methylated B12 Nutrient Injections

Vitamin B12 is a required cofactor by gut microbes for various biological processes, including acetate production and for conversion of succinate to proprionate.  (1 injection IM / 2 x week / 12 weeks)

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