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Age Management of West Michigan

Integrative Medicine

Conventional, Functional, and Anti-Aging Regenerative Medicine located in Grand Rapids, MI.
Dr. Shahnaz Ali            Dr. Piyush Bhatnagar

Numerous clinical studies have shown that Selank has strong antianxiety and neuroprotective effects in the treatment of generalized anxiety disorders.


Selank is a peptide analog of the human tetrapeptide Tuftsin and mimics many of Tuftsin's anxiolytic and immune modulating benefits.   Selank's primary application is for its anti-anxiety and anti-depressant effects on stress resilience and mood.   One molecular mechanism by which Selank operates is by allosterically modulating the GABAergic system.  Selank also acts through the dopamine and serotonergic systems, which is why Selank has similar physiological effects as classical benzodiazepines.  Selank does not interact with GABA receptors the same way as benzodiazepines, but has very similar anxiolytic and antidepressant effects.  Thus, side effects such as abuse potential and tolerance, which are common with benzodiazepines, do not seem to occur with Selank.  It also modulates the expression of Interleukin-6 (IL-6), affects the balance of T helper cell cytokines, and influences the concentration of monoamine neurotransmitters and serotonin metabolism.

Selank  also increases cognitive abilities by increasing production of BDNF (Brain-Derived Neurotrophic Factor).   

Selank Benefits

  • Decrease Anxiety

  • Decrease Depression

  • Decrease Stress and Improve Body's Stress Resilience

  • Improve Cognitive Performance

  • Improved Memory and Recall

  • Prevent weight gain and reduce cholesterol

  • Decreases alcohol-withdrawal-related anxiety

  • Decreased blood pressure and increase brain blood flow

  • Increased Immune System Function

  • Improved energy and motivation in CFS

  • Improved symptoms of Neurasthenia

  • Increase BDNF 

  • Improved Sleep

  • Improved Focus and Concentration

  • Helps to increase lymph flow to the stomach and decrease stomach ulcers

  • Stabilizes blood enkephalins - natural peptides that can reduce stress

Selank is safe

Selank has a high safety profile and is practically non-toxic since it breaks down in the body into amio acids.  Selank has been recommended by Russian and Ukraine doctors for more than a decade and is availalble in Russia as an over the counter medication, available without prescription.  Numerous clinical trials confirmed the safety of this peptide, which was found to not form a dependence and to be non-toxic even in doses 200-500 times higher than the therapeutic ones.

Selank does not cause drowsiness, lethargy, dull thinking, and other side effects associated with most medications used to treat neurological and mental disorders.  Selank does not cause addiction or withdrawal symptoms,

Selank is compatible with other medications

Selank is compatible to be used with various medications to treat cognitive and neurological disorders.   Selank has a positive effect when utilized in combination with other medications by alleviating withdrawal symptoms and reducing side effects.  Selank can be safely utilized along with consumption of alcohol and helps offset the toxicity of alcohol on brain function.

Selank Administration

Selank is administered by nasal spray through the nasal mucosa. The effectiveness of intranasal administration is higher than other methods (tablet or IM), because this mode of administration ensures the rapid transport of the active substance directly into the brain tissue along the olfactory nerves.   Selank effects can be noticed within 15 to 30 minutes after administration.

Dosing:  2 Week Cycle

Days 1-4:  One spray in each nostril / 1 x daily /  Morning on an empty stomach

Days 5-14:  One spray in each nostril / 2 x daily / Morning and Afternoon on an empty stomach


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Research and References
  1. Kozlovskaya MM et al (2003). Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress.

  2. Medvedev VE et al (2015). Optimization of the treatment of anxiety disorders with Selank.

  3. Tereshchenko ON et al (2014). A comparison of the anxiolytic effect and tolerability of Selank and phenazepam in the treatment of anxiety disorders. I et al (1978). 

  4. Polak JM, Bloom SR (1986). Regulatory peptides of the gastrointestinal and respiratory tracts.

  5. Najjar VA, Nishioka K (1970). Tuftsin a natural phagocytosis stimulating peptide.

  6. Zozulia AA et al (2008).Efficacy and possible mechanisms of action of a new peptide anxiolytic Selank in the therapy of generalized anxiety disorders and neurasthenia.

  7. Semenova TP et al (2009). Comparison of the effects of Selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA.

  8. Ershov FI et al (2009). Antiviral activity of immunomodulator Selank in experimental influenza infection.

  9. Neznamov GG et al (2011). Selank – original peptide anxiolytic.

  10. Mezentseva MV et al (2011). Neurotropic peptide called Selank with antiviral activity against human and bird influenza and herpes virus infections.

  11. Wu M et al (2012). Tuftsin Promotes an Anti-Inflammatory Switch and Attenuates Symptoms in Experimental Autoimmune Encephalomyelitis.!po = 32.926831.

  12. In vivo immunostimulation by tuftsin.

  13. Kolik LG et al (2014). Efficacy of peptide anxiolytic Selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation.

  14. Lalayan T, Korzhavina N (2014). The influence of Selank on the course of pain syndrome in patients with chronic pain syndromes of lumbosacral spine.

  15. Selye H (1974). Stress Without Distress.

  16. Verbenko VA, Phedorov VN (2016). The using a new anxiolytic peptide “Selank” in the therapy of psychogenic binge eating disorder.

  17. Fomenko EV et al (2017). Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress.

  18. Verbenko VA, Shakina TA (2017). Effectiveness of new synthesized analogue of endogenous peptide taftcin – Selank in therapy of adjustment and posttraumatic stress disorders.

  19. Verbenko VA, Shakina TA (2019). New opportunities to potentiate the action of selective serotonin reuptake inhibitors by Selank regulatory peptide in the therapy of anxious-depressive disorders.

  20. Starikov P, Fedorov V (2019). The use of Selank in the treatment of vegetative and psycho-emotional disorders in climacteric syndrome in women.

  21. Siebert A et al (2017). Tuftsin – Properties and Analogs.

  22. Yasenyavskaya AL et al (2020). The Influence of Selank on the Level of Cytokines Under the Conditions of Social Stress.

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